Search results for "Dual role"

Dual role of silver in a fluorogenic N-squaraine probe based on Ag(i)–π interactions

2021

In the presence of Ag(I), the monoanion of cyano-N-squaraine (I) generates an intense fluorescence turn-on response. Experimental evidence and DFT calculations reveal a sequence of deprotonation-coordination events in which the Ag(I) ions play a dual role as a Lewis acid and coordinating metal. The observed effect is highly selective for Ag(I) compared to other metals.

Extracellular vesicles: small bricks for tissue repair/regeneration

2017

Extracellular vesicles (EVs) are nano-sized membrane vesicles involved in intercellular communication. EVs have pleiotropic actions in physiological and pathological conditions. The ability of EVs to transports proteins, drugs and nucleic acid, to target specific cells and to increase the stability of therapeutic cargo, make EVs interesting as new devices for the treatment of human disease. In a recently published issue of European journal of pharmaceutical sciences, Silva and colleagues reviewed the ability of EVs to modulate tissue repair and regeneration, focusing on their roles and therapeutic potential as immunomodulatory messengers. In this perspective, we discussed the open questions…

Contributo para o estudo psicométrico da versão portuguesa do Cuestionario de Satisfacción Laboral S20/23

2010

Job satisfaction is understood through its dual role on organization productivity and employees achievement (Smith, 1998). The use of instruments to measure it in Portugal, has been the subject of several studies, such as the adaptation of the Cuestionario de Satisfacción Laboral S20/23 (Meliá & Peiró, 1989) to Portuguese population carried out by Pocinho and García (2008). This study is a further contribution to the study of the psychometric qualities of this instrument. The results on a sample of 136 Portuguese employees show that the questionnaire presents the adequate requirements of internal consistency (.95), test-retest reliability, and convergent validity (correlation of .84 with th…

Digital Resilience to Normal Accidents in High-Reliability Organizations

2021

Digital technologies play a dual role on organizational resilience. On one side, digital systems introduce new technological risks. On the other side, digital systems increase the performances in response to hazardous accidents. Normal Accident Theory (NAT) and High-Reliability Organization (HRO) provide useful ground to explain the dynamics of digital resilience. However, the two theories have been either used as alternatives or with one theory dominating the other. We posit that to fully understand digital resilience we need to integrate NAT and HRO concepts instead of using them in isolation. We conduct a bibliometric analysis to identify major themes and application domains characterizi…

Highly convergent total synthesis of (+)-anaferine and (−)-dihydrocuscohygrine

2019

A unified and highly convergent total synthesis of anaferine and dihydrocuscohygrine alkaloids has been devised, taking advantage of the dual role of N-sulfinyl amines as nucleophilic nitrogen sources and chiral auxiliaries. A bidirectional cross metathesis reaction followed by a double intramolecular aza-Michael reaction led us to create the whole skeleton of the natural products in a very simple manner.

Dual Role of Vinyl Sulfonamides as N -Nucleophiles and Michael Acceptors in the Enantioselective Synthesis of Bicyclic δ-Sultams

2018

WT1 isoform expression pattern in acute myeloid leukemia.

2013

WT1 plays a dual role in leukemia development, probably due to an imbalance in the expression of the 4 main WT1 isoforms. We quantify their expression and evaluate them in a series of AML patients. Our data showed a predominant expression of isoform D in AML, although in a lower quantity than in normal CD34+ cells. We found a positive correlation between the total WT1 expression and A, B and C isoforms. The overexpression of WT1 in AML might be due to a relative increase in A, B and C isoforms, together with a relative decrease in isoform D expression.

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene.

1977

The effect of epoxide hydratase upon the mutagenicity of benzo(a)pyrene was investigated using two Salmonella typhimurium strains (TA 1537 and TA 98). These two bacterial strains were found to differ characteristically in their susceptibility to different mutagens biologically produced from benzo(a)pyrene providing a diagnostic tool to investigate which types of mutagenic metabolites were produced in various metabolic situations. The results showed that the pattern of mutagenic metabolites produced by microsomes from methylcholanthrene-treated mice was very different from that produced by microsomes from phenobarbital-treated or untreated mice. However in all cases at least two mutagenic me…

Bullying and social anxiety experiences in university learning situations

2019

This study examines how individuals’ engagement in bullying at school and at university relates to the anxiety they feel in general and in various learning situations in which students interact during their higher education. It was predicted that, of the individuals who have experiences of bullying (in the role of bully, victim, or in a dual role as bully-victim), those who have been subjected to bullying experience more anxiety than do those who have no experience with bullying. A nationally representative sample of Finnish university students (N = 5086) participated in the study by responding to survey questions assessing their experiences of (a) anxiety syndrome, (b) context-specific soc…

Halogen‐Imparted Reactivity in Lithium Carbenoid Mediated Homologations of Imine Surrogates: Direct Assembly of bis‐Trifluoromethyl‐β‐Diketiminates a…

2020

The selective formal insertion (homologation) of a carbon unit bridging the two trifluoroacetamidoyl chlorides (TFAICs) units is reported. The tactic is levered on a highly chemoselective homologation-metalation-acyl nucleophilic substitution sequence which precisely enables to assemble novel trifluoromethylated β-diketiminates within a single synthetic operation. Unlike previous homologations conducted with LiCH2Cl furnishing aziridines, herein we exploit the unique capability of iodomethyllithium to act contemporaneously as a C1 source (homologating effect) and metalating agent. The mechanistic rationale grounded on experimental evidences supports the hypothesized proposal and, the struct…